The effect of neutrophil serine proteases on human nasal epithelial cell barrier function.

Stephen Shih-Teng KaoMahnaz RamezanpourAhmed BassiouniPeter-John WormaldAlkis James PsaltisSarah Vreugde

Published in: International forum of allergy & rhinology (2019)

Serine proteases derived from neutrophils and from P. aeruginosa showed detrimental effects on the mucosal barrier integrity with increased permeability, allowing for potential bacterial invasion. This finding may further assist in understanding the pathophysiology present in chronic inflammatory airway diseases.

Keyphrases

endothelial cells
protein kinase
induced pluripotent stem cells
cell migration
ulcerative colitis
human health
drug induced