Altered Amygdala Volumes and Microstructure in Focal Epilepsy Patients with Tonic-Clonic Seizures, Ictal and Post-Ictal Central Apnea.

Claudia ZeicuAntoine LegouhyCatherine A ScottJoana F A OliveiraGavin WinstonJohn S DuncanSjoerd B VosMaria ThomSamden LhatooHui ZhangRonald M HarperBeate Diehl

Published in: medRxiv : the preprint server for health sciences (2023)

Individuals with FBTCS and PICA show significantly increased amygdala volumes and disrupted architecture bilaterally, with greater changes on the left side. The structural alterations reflected by NODDI and volume differences may be associated with inappropriate cardiorespiratory patterns mediated by the amygdala, particularly after FBTCS. Determination of amygdala volumetric and architectural changes may assist identification of individuals at risk.

Keyphrases

temporal lobe epilepsy
functional connectivity
resting state
prefrontal cortex
white matter
body composition
high intensity
molecularly imprinted
mass spectrometry
sleep apnea