Sex- and age-associated factors drive the pathophysiology of MASLD.
Ajay K YadavJustin J MacNeillAleksei KrylovNadia AshrafiRomana Ashrafi MimiRomil SaxenaSheng LiuStewart Francis GrahamJun WanNúria MorralPublished in: Hepatology communications (2024)
Here, we show distinct responses to an HFD between males and females. Our study underscores the need for using both sexes in drug target identification studies, and characterizing the molecular mechanisms contributing to the MASLD pathophysiology in aging animals.