High risk of patient self-inflicted lung injury in COVID-19 with frequently encountered spontaneous breathing patterns: a computational modelling study.
Liam WeaverAnup DasSina SaffaranNadir YehyaTimothy E ScottMarc ChikhaniJohn G LaffeyJonathan G HardmanLuigi CamporotaDeclan G BatesPublished in: Annals of intensive care (2021)
Our results suggest that the forces generated by increased inspiratory effort commonly seen in COVID-19 acute hypoxaemic respiratory failure are comparable with those that have been associated with ventilator-induced lung injury during mechanical ventilation. Respiratory efforts in these patients should be carefully monitored and controlled to minimise the risk of lung injury.
Keyphrases
- respiratory failure
- mechanical ventilation
- acute respiratory distress syndrome
- intensive care unit
- coronavirus disease
- extracorporeal membrane oxygenation
- sars cov
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- patient reported outcomes
- diabetic rats
- liver failure
- respiratory syndrome coronavirus
- aortic dissection