Histone deacetylase inhibition leads to regulatory histone mark alterations and impairs meiosis in oocytes.

Louis LegoffOuzna DaliElena De La Mata SantaellaChristian JaulinShereen Cynthia D'CruzFatima Smagulova

Published in: Epigenetics & chromatin (2021)

Our data suggest that inhibition of histone deacetylase by PB during a critical developmental window affects reprogramming and germ cell specification via alteration of epigenetic marks.

Keyphrases

histone deacetylase
germ cell
dna methylation
gene expression
heavy metals
electronic health record
transcription factor
big data
risk assessment
machine learning
aqueous solution