Hyperinsulinemia promotes aberrant histone acetylation in triple-negative breast cancer.

Parijat SenapatiHiroyuki KatoMichael LeeAmy LeungChristine ThaiAngelica SanchezEmily J GallagherDerek LeRoithVictoria L SeewaldtDavid K AnnDustin E Schones

Published in: Epigenetics & chromatin (2019)

These results demonstrate the impact of hyperinsulinemia on altered gene regulation through chromatin and the importance of targeting hyperinsulinemia-induced processes that lead to chromatin dysfunction in TNBC.

Keyphrases

dna damage
gene expression
transcription factor
genome wide
dna methylation
high glucose
diabetic rats
oxidative stress
cancer therapy
endothelial cells