NUDT15 C415T variant compared with TPMT genotyping in predicting azathioprine-induced leucopenia: prospective analysis of 1014 inflammatory bowel disease patients in India.

Rupa BanerjeeVishnubhotla Venkata RavikanthPartha PalGovardhan BaleUrmila Steffie AvanthiIdan GorenB Ganesh GirishSasikala MitnalaD Nageshwar Reddy

Published in: Alimentary pharmacology & therapeutics (2020)

NUDT15 variant genotyping appears to be a better predictor for azathioprine-induced leucopenia in an Indian population than TPMT with high accuracy and can be useful in optimizing azathioprine dosage.

Keyphrases

high glucose
diabetic rats
end stage renal disease
high throughput

newly diagnosed
ejection fraction
genome wide
drug induced

prognostic factors
peritoneal dialysis
oxidative stress
endothelial cells

dna methylation
genetic diversity
stress induced
patient reported