Enhancement of CAR-T cell activity against cholangiocarcinoma by simultaneous knockdown of six inhibitory membrane proteins.
Yidan QiaoJie ChenXuemei WangShumei YanJizhou TanBaijin XiaYongjian ChenKeming LinFan ZouBingfeng LiuXin HeYiwen ZhangXu ZhangHui ZhangXiangyuan WuLijuan LuPublished in: Cancer communications (London, England) (2023)
Our results revealed that PTG-T16R-scFV-CAR-T cells with knockdown of sextuplet inhibitory molecules exhibited strong immunity against cholangiocarcinoma and long-term efficacy both in vitro and in vivo. This strategy provides an effective and personalized immune cell therapy against cholangiocarcinoma.