Kindlin-3 stokes the life span of podosomes.

Published in: The Journal of cell biology (2019)

Macrophages and other cell types can form podosomes, highly dynamic adhesive structures that mediate the interaction of these cells with the surrounding matrix. In this issue, Klapproth et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201903109) find that kindlin-3 regulates podosome stability by recruiting leupaxin, with concomitant effects on PTP-PEST phosphatase activity and paxillin phosphorylation.

Keyphrases

single cell
cell therapy
induced apoptosis
cell cycle arrest
oxidative stress
cell death
mesenchymal stem cells