Cathelicidin-BF enhances TFEB-mediated autophagy and alleviates ROS-induced pyroptosis after ischemia-reperfusion injury of island skin flaps.

Ningning YangGaoxiang YuYingying LaiJiayi ZhaoZhuliu ChenLiang ChenYuedong FuPin FangWeiyang GaoYuepiao CaiZhijie LiZhou-Guang WangKailiang ZhouJian Ding

Published in: British journal of pharmacology (2023)

BF-30 promotes I/R-injured skin flaps survival by TFEB-mediated upregulation of autophagy and inhibition of oxidative stress, which may have possible clinical applications.

Keyphrases

oxidative stress
soft tissue
ischemia reperfusion injury
diabetic rats
cell death
dna damage
signaling pathway
endoplasmic reticulum stress
induced apoptosis
wound healing
high glucose
cell proliferation
reactive oxygen species
nlrp inflammasome
breast reconstruction
free survival
heat shock