Clinical Responsiveness to All-trans Retinoic Acid Is Potentiated by LSD1 Inhibition and Associated with a Quiescent Transcriptome in Myeloid Malignancies.

Mina Masoumeh TayariHelena G Dos SantosDeukwoo KwonTerrence J BradleyAmber ThomassenCharles ChenYvonne DinhAymee PerezArthur ZelentLluis MoreyLuisa CimminoRamin ShiekhattarRonan T SwordsJustin M Watts

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

These data indicate that LSD1 inhibition sensitizes AML cells to ATRA and may restore ATRA responsiveness in subsets of patients with MDS and AML.

Keyphrases

acute myeloid leukemia
induced apoptosis
cell cycle arrest
allogeneic hematopoietic stem cell transplantation
signaling pathway
gene expression
oxidative stress
electronic health record
bone marrow
rna seq
genome wide
peripheral blood
single cell
cell death
dna methylation
data analysis