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Functional biomarker signatures of circulating T-cells and its association with distinct clinical status of leprosy patients and their respective household contacts.

Pedro Henrique Ferreira MarçalRafael Silva GamaLorena Bruna Pereira de OliveiraOlindo Assis Martins-FilhoRoberta Olmo PinheiroEuzenir Nunes SarnoMilton Ozório MoraesLucia Alves de Oliveira Fraga
Published in: Infectious diseases of poverty (2020)
Our data demonstrated that L(PB) displayed enhanced percentage of IFN-γ+, IL-10+ and IL-4+ as compared to L(MB) that presented functional profile mediated by IL-10+ and IL-4+ T-cells and HHC(MB) exhibited enhanced frequency of IFN-γ+ T-cells, contrasting with HHC(PB). Together, our findings provide additional immunological features associated with leprosy and household contacts. These data provide evidence that biomarkers of immune response can be useful complementary diagnostic/prognostic tools as well as insights that household contacts should be monitored to access putative subclinical infection.
Keyphrases
  • immune response
  • dendritic cells
  • heavy metals
  • end stage renal disease
  • electronic health record
  • newly diagnosed
  • big data
  • machine learning
  • patient reported outcomes