Apolipoprotein E and Cerebral Small Vessel Disease Markers in Patients With Intracerebral Haemorrhage.

Isabel Charlotte Hostettler David Julian SeiffgeAndrew WongGareth AmblerDuncan WilsonClare ShakeshaftGargi Banerjee Nikhil SharmaHans Rudolf JägerHannah CohenTarek A YousryRustam Al-Shahi Salman Gregory Yoke Hong LipMartin M BrownKeith W Muir Henry HouldenDavid Werring

Published in: Neurology (2022)

We confirmed associations between APOE alleles and ICH including lobar ICH. Our analysis shows selective associations between APOE ε2 and ε4 alleles with FLP, a CT marker of CAA. Our findings suggest that different APOE alleles might have diverging influences on individual neuroimaging biomarkers of CAA-associated ICH.

Keyphrases

cognitive decline
high fat diet
mild cognitive impairment
computed tomography
subarachnoid hemorrhage
image quality
adipose tissue
type diabetes
brain injury
metabolic syndrome
skeletal muscle
blood brain barrier