High rates of extensively drug-resistant Acinetobacter baumannii in a Peruvian hospital 2013-2019.
Rodrigo Samuel Barrientos-YongBryan Andrei Hinojosa-SalasPercy Genaro Salas-PonceEddie AnglesJoaquim RuizMaría J PonsPublished in: Tropical doctor (2022)
Multidrug-resistant (MDR) Acinetobacter baumannii has become a major concern of hospital care. The objective of the study was to evaluate the evolution of antimicrobial resistance of A. baumannii in a Peruvian hospital from 2013 to 2019. A total of 993 A. baumannii clinical isolates were recovered. Antimicrobial resistance levels were extremely high, except for colistin. Among the remaining antibacterial agents, ampicillin plus sulbactam (AMS) was the most active (71.4% of resistance), with resistance levels to the remaining agents ranging from 75.9% to amikacin to 99.2% to ertapenem. The presence of significant differences was observed in extensively drug-resistant (XDR) A. baumannii according to samples origin. No association was observed between MDR or XDR isolates and seasonality. An impressive rate of XDR A. baumannii isolates was found, including a growing number of only-colistin-susceptible isolates highlighting the urgent need for new therapeutic alternatives.
Keyphrases
- drug resistant
- multidrug resistant
- acinetobacter baumannii
- antimicrobial resistance
- gram negative
- healthcare
- klebsiella pneumoniae
- genetic diversity
- acute care
- adverse drug
- palliative care
- quality improvement
- escherichia coli
- pain management
- pseudomonas aeruginosa
- cystic fibrosis
- electronic health record
- drug induced