Next-generation sequencing of prolidase gene identifies novel and common variants associated with low prolidase in coronary artery ectasia.
Kubra Cigdem Pekkoc-UyanikEzgi Irmak AslanOnur KilicarslanOzgur Selim SerSerhan OzyildirimFatih YanarAhmet YildizOguz OzturkHülya Yılmaz-AydoğanPublished in: Molecular biology reports (2022)
Our findings indicate that the low serum prolidase levels observed in CAE patients is significantly associated with PEPD gene variations. It was concluded that low serum prolidase level and associated PEPD mutations may be potential biomarkers for the diagnosis of CAE.