The Pattern of RNA Editing Changes in Pleural Mesothelioma upon Epithelial-Mesenchymal Transition.
Emanuela Felley-BoscoWeihong QiDidier JeanClément MeillerHubert RehrauerPublished in: International journal of molecular sciences (2023)
Pleural mesothelioma (PM) is a cancer where epithelioid, biphasic and sarcomatoid histotypes are observed. Sarcomatoid PM is characterized by mesenchymal features. Multi-omics have been used to characterize the epithelial-to-mesenchymal (EMT) phenotype at the molecular level. We contribute to this effort by including the analysis of RNA editing. We extracted samples with the highest vs. lowest Epithelial score from two PM cohorts and observed increased RNA editing in introns and decreased RNA editing in 3'UTR upon EMT. The same was observed in primary PM primary cultures stratified by transcriptomics analysis into two groups, one of them enriched with mesenchymal features. Our data demonstrate that, as has been observed in other cancer types, RNA editing associates to EMT phenotype in PM.
Keyphrases
- crispr cas
- epithelial mesenchymal transition
- particulate matter
- air pollution
- polycyclic aromatic hydrocarbons
- heavy metals
- bone marrow
- stem cells
- papillary thyroid
- water soluble
- single cell
- transforming growth factor
- nucleic acid
- signaling pathway
- squamous cell carcinoma
- machine learning
- big data
- artificial intelligence
- electronic health record
- childhood cancer