Identifying optimal dosing strategies for meropenem in the paediatric intensive care unit through modelling and simulation.

Ronaldo Morales JuniorTomoyuki MizunoKelli M PaiceKathryn E PaviaH Rhodes HambrickPeter TangRhonda JonesAbigayle GibsonErin StonemanCalise CurryJennifer KaplanSonya C Tang Girdwood

Published in: The Journal of antimicrobial chemotherapy (2024)

We successfully developed a population pharmacokinetic model of meropenem using real-world data from critically ill paediatric and young adult patients with an opportunistic sampling strategy and provided dosing recommendations based on the patients' renal function and fluid status.

Keyphrases

intensive care unit
end stage renal disease
emergency department
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
mechanical ventilation
gram negative
electronic health record
clinical practice
patient reported outcomes
middle aged
deep learning
data analysis