Advanced glycation end product-modified low-density lipoprotein promotes pro-osteogenic reprogramming via RAGE/NF-κB pathway and exaggerates aortic valve calcification in hamsters.
Xi YangJingxin ZengKaiji XieShuwen SuYuyang GuoHao ZhangJun ChenZhuang MaZezhou XiaoPeng ZhuShaoyi ZhengDingli XuQingchun ZengPublished in: Molecular medicine (Cambridge, Mass.) (2024)
AGE-LDL promoted inflammatory responses and osteogenic differentiation through RAGE/NF-κB pathway in vitro and aortic valve lesions in vivo. IL-37 suppressed the AGE-LDL-induced inflammatory and osteogenic responses in vitro and attenuated aortic valve lesions in a hamster model of CAVD.
Keyphrases
- aortic valve
- low density lipoprotein
- mesenchymal stem cells
- bone marrow
- transcatheter aortic valve replacement
- transcatheter aortic valve implantation
- aortic valve replacement
- aortic stenosis
- signaling pathway
- oxidative stress
- lps induced
- pi k akt
- diabetic rats
- nuclear factor
- high glucose
- chronic kidney disease
- heart failure
- drug induced
- endothelial cells
- left ventricular
- cell proliferation