TNF-α polymorphisms affect persistence and progression of HBV infection.
Anna WoziwodzkaMagda RybickaAlicja SznarkowskaTomasz RomanowskiMarcin DręczewskiPiotr StalkeKrzysztof Piotr BielawskiPublished in: Molecular genetics & genomic medicine (2019)
This study indicates that TNF-α -863A and -1031C alleles are associated with increased susceptibility to CHB in individuals from northern Poland. The same variants determine the course of CHB, lowering viremia and reducing necroinflammatory activity of the liver.