Maternal Isocaloric High-Fat Diet Induces Liver Mitochondria Maladaptations and Homeostatic Disturbances Intensifying Mitochondria Damage in Response to Fructose Intake in Adult Male Rat Offspring.

Aline F P SouzaJuliana WoyamesRosiane A MirandaLorraine S OliveiraBruna CaetanoIsabela L MartinsManuella S SouzaCherley B V AndradeThais Bento-BernardesFlavia F BloiseRodrigo S FortunatoIsis H TrevenzoliLuana L SouzaCarmen Cabanelas Pazos-Moura

Published in: Molecular nutrition & food research (2022)

Mitochondrial dysfunction and homeostatic disturbances in response to fructose are early events evidencing the higher risk of fructose damage in the liver of adult offspring from dams fed an isocaloric moderate high-fat diet.

Keyphrases

high fat diet
insulin resistance
adipose tissue
oxidative stress
cell death
reactive oxygen species
childhood cancer
high intensity
metabolic syndrome
birth weight
pregnancy outcomes