Gut virome-colonising Orthohepadnavirus genus is associated with ulcerative colitis pathogenesis and induces intestinal inflammation in vivo .
Luca MassiminoOrazio PalmieriAmanda FacoettiDavide FuggettaSalvatore SpanòLuigi Antonio LamparelliSilvia D'AlessioStefania CaglianiFederica FurfaroFerdinando D'AmicoAlessandra ZilliGionata FiorinoTommaso Lorenzo ParigiDaniele NovielloAnna LatianoFabrizio BossaTiziana LatianoAlessandra PirolaLuca MologniRocco Giovanni PiazzaDanilo AbbatiFrancesco PerriChiara BoniniLaurent Peyrin BirouletAlberto MalesciVipul JairathMarjorie Costa ArgolloFederica UngaroPublished in: Gut (2023)
This study described HBx as a contributor to the UC pathogenesis and provides a new perspective on the virome as a target for tailored treatments.