Multiple Genetic Mutations Associated with Polymyxin Resistance in Acinetobacter baumannii.
Tze Peng LimRick Twee-Hee OngPei-Yun HonJane HawkeyKathryn E HoltTse Hsien KohMicky Lo-Ngah LeongJocelyn Qi-Min TeoThean Yen TanMary Mah-Lee NgLi Yang HsuPublished in: Antimicrobial agents and chemotherapy (2015)
We studied polymyxin B resistance in 10 pairs of clinical Acinetobacter baumannii isolates, two of which had developed polymyxin B resistance in vivo. All polymyxin B-resistant isolates had lower growth rates than and substitution mutations in the lpx or pmrB gene compared to their parent isolates. There were significant differences in terms of antibiotic susceptibility and genetic determinants of resistance in A. baumannii isolates that had developed polymyxin B resistance in vivo compared to isolates that had developed polymyxin B resistance in vitro.