Spatial resolution of renal amyloid deposits through MALDI-MSI: a combined digital and molecular approach to monoclonal gammopathies.

Greta BindiAndrew SmithGlenda OliveiraAlbino EccherSimona VatranoFederico AlbericiGiorgio CazzanigaStefania GalimbertiGiulia CapitoliFulvio MagniFabio Pagni Vincenzo L'Imperio

Published in: Journal of clinical pathology (2023)

MALDI-MSI correctly assigned minimal/challenging cases of amyloidosis to the correct type (AL lambda) and identified lambda light chains in LCDD cases, highlighting the promising role of MALDI-MSI for amyloid typing.

Keyphrases

mass spectrometry
multiple myeloma
single molecule