Propionibacterium acnes overabundance in gastric cancer promote M2 polarization of macrophages via a TLR4/PI3K/Akt signaling.

Qing LiWei WuDexin GongRenduo ShangJing WangHong Gang Yu

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2021)

Together, our finding identified that P. acnes could be a possible agent for the progression of GC besides H. pylori. M2 polarization of macrophages could be promoted by P. acnes via TLR4/PI3K/Akt signaling, thus triggers the progression of GC.

Keyphrases

pi k akt
signaling pathway
cell cycle arrest
cell proliferation
toll like receptor
inflammatory response
immune response
gas chromatography
nuclear factor
cell death