Repurposing an Antiviral Drug against SARS-CoV-2 Main Protease.

Published in: Angewandte Chemie (International ed. in English) (2021)

This article highlights recent pioneering work by Günther et al. towards the discovery of potential repurposed antiviral compounds (peptidomimetic and non-peptidic) against the SARS-CoV-2 main protease (Mpro ). The antiviral activity of the most potent drugs is discussed along with their binding mode to Mpro as observed through X-ray crystallographic screening.

Keyphrases

sars cov
respiratory syndrome coronavirus
small molecule
magnetic resonance imaging
magnetic resonance
drug induced
coronavirus disease
computed tomography
anti inflammatory
dual energy
mass spectrometry
climate change
human health
single cell