Broader phenotypic traits and widespread brain hypometabolism in spinocerebellar ataxia 27.

Martin PaucarJ LundinT AlshammariÅ BergendalM LindefeldtM AlshammariG SoldersJ Di ReI SavitchevaT GranbergF LaezzaE IwarssonP Svenningsson

Published in: Journal of internal medicine (2020)

This is the second largest SCA27 family identified to date. We provide new clinical and preclinical evidence for a significant psychiatric component in SCA27, strengthening the hypothesis of FGF14 as an important modulator of psychiatric disease.

Keyphrases

mental health
white matter
resting state
genome wide
early onset
cell therapy
stem cells
multiple sclerosis
mesenchymal stem cells
blood brain barrier