Relationship between smoking and ALS: Mendelian randomisation interrogation of causality.
Sarah Opie-MartinRobyn E WoottonAshley Budu-AggreyAleksey ShatunovAshley R JonesAlfredo IacoangeliAhmad Al KhleifatGeorge Davey-SmithAmmar Al ChalabiPublished in: Journal of neurology, neurosurgery, and psychiatry (2020)
Using multiple methods, large sample sizes and sensitivity analyses, we find no evidence with Mendelian randomisation techniques that smoking causes ALS. Other smoking phenotypes, such as current smoking, may be suitable for future Mendelian randomisation studies.