Methylation status and long-fragment cell-free DNA are prognostic biomarkers for gastric cancer.

Kazuhide KoYoshikazu KananazawaTakeshi YamadaDaisuke KakinumaKunihiko MatsunoFumihiko AndoSho KuriyamaAkihisa MatsudaHiroshi Yoshida

Published in: Cancer medicine (2021)

Pre-surgical low methylation levels of LINE-1 are a negative prognostic factor. Post-surgical high concentrations of long-fragment LINE-1 indicate MRD and a high risk of recurrence.

Keyphrases

prognostic factors
genome wide
dna methylation
gene expression