Difference in Profiles of the Gut-Derived Tryptophan Metabolite Indole Acetic Acid between Transplanted and Non-Transplanted Patients with Chronic Kidney Disease.

Sophie Liabeuf Solène M Laville Griet GlorieuxLynda CheddaniFrançois BrazierDimitri Titeca BeauportRaymond ValholderGabriel ChoukrounZiad A Massy

Published in: International journal of molecular sciences (2020)

We demonstrated that levels of IAA increase with the CKD stage, and fall substantially, even normalizing, after kidney transplantation. Free IAA appears to be a valuable outcome-associated biomarker in non-transplanted patients, but-at least in our study setting-not in transplanted patients.

Keyphrases

end stage renal disease
chronic kidney disease
newly diagnosed
ejection fraction
prognostic factors
patient reported