Lysosome-associated membrane protein 3 misexpression in salivary glands induces a Sjögren's syndrome-like phenotype in mice.
Hiroyuki NakamuraTsutomu TanakaThomas PranzatelliYoungmi JiHongen YinPaola PerezSandra A AfioneShyh-Ing JangCorrine GoldsmithChang Yu ZhengWilliam D SwaimBlake M WarnerNoriyuki HirataMasayuki NoguchiTatsuya AtsumiJohn A ChioriniPublished in: Annals of the rheumatic diseases (2021)
These results show a critical role for lysosomal trafficking in the development of SS and establish a causal relationship between LAMP3 misexpression and the development of SS.