Monitoring of estradiol levels in premenopausal women receiving adjuvant abemaciclib and ovarian function suppression.

Alaina J KesslerRima PatelEmily Jane GallagherTianxiang ShengDamodara Rao MenduAmy TierstenPaula KleinAarti S BhardwajAnupama GoelJoseph A SparanoTheresa ShaoJulie Fasano

Published in: Breast cancer research and treatment (2024)

Our findings suggest the likely interference of abemaciclib with the Abbott Alinity immunoassay which may lead to unnecessary treatment changes. It is recommended that the LC-MS/MS assay be used when monitoring estradiol levels in patients receiving abemaciclib concurrently with OFS.

Keyphrases

estrogen receptor
early stage
polycystic ovary syndrome
high throughput
breast cancer risk
type diabetes
pregnant women
skeletal muscle
sensitive detection
replacement therapy
single cell