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Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging.

Tobias GustavssonMatthias M HerthDag SehlinStina Syvänen
Published in: Upsala journal of medical sciences (2024)
In]biAb in bone marrow and intracellular accumulation in brain tissue indicated some off-target interactions or potential interaction with intrabrain TfR resulting in a relatively high non-specific background signal.
Keyphrases
  • bone marrow
  • resting state
  • white matter
  • functional connectivity
  • mesenchymal stem cells
  • pet ct
  • multiple sclerosis
  • reactive oxygen species
  • human health
  • fluorescence imaging