A One-Pot Multicomponent 1,3-Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Dihydrothiophenone-Engrafted Dispiro Hybrid Heterocycles.

Mani Anusha RaniSundaravel Vivek KumarKaruppiah MalathiMuthumani MuthuAbdulrahman I AlmansourRaju Suresh KumarRaju Ranjith Kumar

Published in: ACS combinatorial science (2017)

The combinatorial syntheses of a library of novel dihydrothiophenone-engrafted dispiro oxindole/indenoquinoxaline-pyrrolidine/pyrrolothiazole/indolizine hybrid heterocycles have been realized through a chemo-, regio-, and stereoselective multicomponent 1,3-dipolar cycloaddition strategy.

Keyphrases

cancer therapy
squamous cell carcinoma
locally advanced
combination therapy
radiation therapy
rectal cancer