Reclassification of a spindle cell sarcoma after identification of a TFG-ROS1 fusion: A case demonstrating the clinical benefit of next-generation sequencing in sarcoma.

John J LimEleanor Y ChenStephanie K SchaubMichael J Wagner

Published in: Molecular genetics & genomic medicine (2024)

We discuss the role of NGS as well as its potential benefit in patients with unresectable, ALK-negative metastatic disease. Considering this case and previous literature, we support the use of NGS for patients requiring systemic treatment.

Keyphrases

end stage renal disease
newly diagnosed
squamous cell carcinoma
ejection fraction
small cell lung cancer
systematic review
dna damage
cell death
prognostic factors
single cell
reactive oxygen species
locally advanced
oxidative stress
dna methylation
genome wide
rectal cancer
tyrosine kinase