Ultrasmall Core-Shell Silica Nanoparticles for Precision Drug Delivery in a High-Grade Malignant Brain Tumor Model.

Rupa JuthaniBrian MadajewskiBarney YooLi ZhangPei-Ming ChenFeng ChenMelik Z TurkerKai MaMichael OverholtzerValerie A LongoSean CarlinVirginia Aragon-SanabriaJason HuseMithat GönenPat ZanzonicoCharles M RudinUlrich WiesnerMichelle S BradburyCameron W Brennan

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

These results demonstrate that highly engineered C' dots are promising drug delivery vehicles capable of navigating the complex physiologic barriers observed in a clinically relevant brain tumor model.

Keyphrases

drug delivery
high grade
cancer therapy
drug release
mass spectrometry
tandem mass spectrometry
iron oxide
light emitting