Effect of small extracellular vesicles derived from IL-10-overexpressing mesenchymal stem cells on experimental autoimmune uveitis.

Yongtao LiXinjun RenZhihui ZhangYanan DuanHuan LiShuang ChenHui ShaoXiaorong LiXiao-Min Zhang

Published in: Stem cell research & therapy (2022)

These results suggested that sEV-IL10 effectively ameliorates EAU by regulating the proliferation and differentiation of T-cells, indicating sEVs as a potential novel therapy for autoimmune uveitis or other autoimmune diseases.

Keyphrases

mesenchymal stem cells
juvenile idiopathic arthritis
ankylosing spondylitis
multiple sclerosis
umbilical cord
signaling pathway
drug induced
bone marrow
mouse model
rheumatoid arthritis
stem cells
disease activity
human health
systemic lupus erythematosus
risk assessment
cell therapy