Interaction between 12p chromosomal abnormalities and Lnc-HOTAIR mediated pathway in acute myeloid leukemia.

Nashwa El-KhazragySherief GhozySafa MatboulyWalid ZakiGehan SafwatGhada HussienOmar Khalifa

Published in: Journal of cellular biochemistry (2019)

12p abnormalities associated AML were associated with worse prognosis. Our results proved that HOTAIR, miR-193a, and c-kit genes are independent prognostic predictors in 12p chromosomal associated AML; therefore it may represent a novel therapeutic application in AML in the future.

Keyphrases

acute myeloid leukemia
allogeneic hematopoietic stem cell transplantation
copy number
cell proliferation
long non coding rna
genome wide
long noncoding rna
current status
dna methylation
acute lymphoblastic leukemia
transcription factor