All-trans retinoic acid exhibits anti-proliferative and differentiating activity in Merkel cell carcinoma cells via retinoid pathway modulation.

Chiara MazziottaGiada BadialeChristian Felice CervelleraGiampaolo MorcianoGiulia Di MauroAntoine TouzéPaolo PintonMauro TognonFernanda Martini John Charles Rotondo

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2024)

These results underline the potential of retinoid-based therapy for MCC management and might open the way to novel experimental approaches with other retinoids and/or combinatorial treatments.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
magnetic resonance imaging
cell death
signaling pathway
computed tomography
human health
magnetic resonance