Euphnerins A and B, Diterpenoids with a 5/6/6 Rearranged Spirocyclic Carbon Skeleton from the Stems of Euphorbia neriifolia.
Min DuLijun AnJing XuYuan-Qiang GuoPublished in: Journal of natural products (2020)
Euphnerins A (1) and B (2), two extremely modified diterpenoids possessing an unprecedented 5/6/6 rearranged spirocyclic carbon skeleton, and a biosynthetically related known diterpenoid (3) were purified from the stems of Euphorbia neriifolia. Their structures were identified by NMR experiments and X-ray diffraction analysis, as well as experimental and calculated electronic circular dichroism data comparison. A putative biosynthetic relationship of 1 and 2 with their presumed precursor 3 is proposed. Compound 1 showed NO inhibitory effects in lipopolysaccharide-stimulated BV-2 cells with an IC50 value of 22.4 μM.
Keyphrases
- high resolution
- induced apoptosis
- lps induced
- cell cycle arrest
- magnetic resonance
- electronic health record
- toll like receptor
- electron microscopy
- lipopolysaccharide induced
- endoplasmic reticulum stress
- big data
- oxidative stress
- cell death
- computed tomography
- mass spectrometry
- solid state
- magnetic resonance imaging
- machine learning
- immune response
- pi k akt
- artificial intelligence
- clinical evaluation