Comparisons of +3179G/A insulin-like growth factor 1 receptor gene distribution between two inflammatory arthritides and healthy adults.

Mariana G Ivanova Irena M Manolova Rumen Malinov Stoilov Spaska A Stanilova

Published in: Archives of rheumatology (2021)

We primarily present an inverse effect of the +3179G/A IGF-1R polymorphism on disease susceptibility to RA and AS, confirming the distinctly different immune pathways involved in the pathogenesis of both inflammatory arthritides. In addition, we could also show trends regarding age- and sex-specific patterns of the rs2229765 genotype distribution in the general population.

Keyphrases

oxidative stress
rheumatoid arthritis
growth hormone
genome wide
binding protein
copy number
disease activity
pi k akt
systemic lupus erythematosus
ankylosing spondylitis
signaling pathway
dna methylation
systemic sclerosis
transcription factor
genome wide analysis