Antiulcer mechanisms of the hydroalcoholic extract from Aztec marigolds' medicinal and edible flowers (Tagetes erecta L.).
Mariane MeurerFabiula FelisbinoFabiana B MüllerLincon B SomensiBenhur J CuryDaniele T JerônimoLarissa VenzonTauani C S FrançaMarihá MariottAna C SantosRuan Kaio S NunesThaise BoeingAlexandre Bella-CruzPriscila DE SouzaWalter A Roman-JuniorKaruppusamy ArunachalamRuberlei Godinho de OliveiraLuisa Mota da SilvaPublished in: Anais da Academia Brasileira de Ciencias (2023)
The antiulcer mechanisms of the dry extract of T. erecta flowers (DETe) were studied here. The acute ulcers induced by acidified ethanol or indomethacin were reproduced in mice pretreated with DETe (3 - 300 mg/kg). The antiulcer activity of DETe was also verified in mice pretreated with NEM, L-NAME, indomethacin, or yohimbine. The antisecretory effect of DETe was verified in rats, and its anti-Helicobacter pylori activity was determined in vitro. DETe (300 mg/kg, p.o) reduced the ethanol- or indomethacin-induced ulcer by 49 and 93%, respectively. The pre-treatment with L-NAME, NEM or yohimbine abolished the gastroprotective effect of DETe. However, DETe did not change the volume, acidity, or peptic activity in rats and did not affect H. pylori. This study expands knowledge about the antiulcerogenic potential of DETe, evidencing the role of nitric oxide, non-protein sulfhydryl groups, α2 adrenergic receptors, and prostaglandins, but not antisecretory or anti-H. pylori properties.
Keyphrases
- helicobacter pylori
- nitric oxide
- oxidative stress
- healthcare
- helicobacter pylori infection
- liver failure
- drug induced
- type diabetes
- risk assessment
- hydrogen peroxide
- insulin resistance
- adipose tissue
- anti inflammatory
- small molecule
- respiratory failure
- acute respiratory distress syndrome
- high glucose
- human health
- protein protein
- nitric oxide synthase
- combination therapy
- wound healing