Voriconazole-Induced Periostitis Mimicking Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation.

Karen I SweissAnnie OhDamiano RondelliPritesh Patel

Published in: Case reports in infectious diseases (2016)

Voriconazole is an established first-line agent for treatment of invasive fungal infections in patients undergoing allogeneic stem cell transplantation (ASCT). It is associated with the uncommon complication of periostitis. We report this complication in a 58-year-old female undergoing HSCT. She was treated with corticosteroids with minimal improvement. The symptoms related to periostitis can mimic chronic graft-versus-host disease in patients undergoing HSCT and clinicians should differentiate this from other diagnoses and promptly discontinue therapy.

Keyphrases

stem cell transplantation
patients undergoing
high dose
drug induced
hematopoietic stem cell
palliative care
high glucose
low dose
endothelial cells
depressive symptoms
replacement therapy