Alterations in DNA damage response and repair genes as potential biomarkers for immune checkpoint blockade in gastrointestinal cancer.
Yujiao WangXi JiaoShuang LiHuan ChenXin WeiChang LiuJifang GongXiaotian ZhangXicheng WangZhi PengChangsong QiZhenghang WangYanni WangNa ZhuoJianling ZouHenghui ZhangJian LiLin ShenZhihao LuPublished in: Cancer biology & medicine (2021)
The DDR gene mutation status was correlated with favorable clinical outcomes in GI cancer patients receiving ICIs, which could serve as a potential biomarker to guide patient selection for immunotherapy.