Facile access to foldable redox-active flavin-peptide conjugates.
Friedrich StrickerJonas Christopher KölschSebastian B BeilSebastian PreißSiegfried R WaldvogelJason SirleafPol BeseniusPublished in: Organic & biomolecular chemistry (2022)
A convenient approach for the synthesis of foldable redox-active flavin peptide conjugates was established. A model β-hairpin oligopeptide motif was utilized to demonstrate that azidolysine side-chains are readily functionalised with an alkyne-bearing flavine derivative. The folding equilibrium of the peptide backbone as well as the redox behaviour of the flavin moieties remains intact after the conjugation.