Direct oral anticoagulants vs. vitamin K antagonists for left ventricular thrombus: a systematic review and meta-analysis.
Angkawipa TrongtorsakSittinun ThangjuiJakrin KewcharoenNatchaya PolpichaiRatdanai YodsuwanVeraprapas KittipibulHarvey J FriedmanAlfonso Q EstradaPublished in: Acta cardiologica (2021)
Our meta-analysis found no significant differences in rates of STE events, LV thrombus resolution, or bleeding events between the use of DOACs and VKAs in LV thrombus. Further randomised controlled trials are needed to confirm our findingsHighlightsThere is limited evidence comparing the use of direct oral anticoagulants (DOACs) to vitamin K antagonists (VKAs) in left ventricular (LV) thrombus.Our systematic review and meta-analysis showed that DOACs are not inferior to VKAs in the incidence of systemic thromboembolism (STE), the rate of LV thrombus resolution, and the risk of bleeding.Current evidence is based on observational studies only. Further randomised controlled trials are needed to confirm the findings.
Keyphrases
- direct oral anticoagulants
- atrial fibrillation
- venous thromboembolism
- left ventricular
- left atrial
- systematic review
- heart failure
- hypertrophic cardiomyopathy
- risk factors
- catheter ablation
- single molecule
- cardiac resynchronization therapy
- coronary artery disease
- aortic stenosis
- percutaneous coronary intervention
- transcatheter aortic valve replacement
- aortic valve