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Non-adjustment for multiple testing in multi-arm trials of distinct treatments: Rationale and justification.

Richard Anthony ParkerChristopher J Weir
Published in: Clinical trials (London, England) (2020)
There is currently a lack of consensus and uncertainty about whether one should adjust for multiple testing in multi-arm trials of distinct treatments. A detailed rationale is presented to justify non-adjustment in this situation. We argue that non-adjustment should be the default starting position in simple multi-arm trials of distinct treatments.
Keyphrases
  • clinical trial
  • clinical practice