Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension: Insights from Comprehensive Multicenter Preclinical Studies.

Sarah-Eve LemayMonica S MontesinosYann GrobsTetsuro YokokawaTsukasa ShimauchiCharlotte RomanetMélanie SauvagetSandra Breuils-BonnetAlice BourgeoisCharlie ThébergeAndréanne PelletierReem El KabboutSandra MartineauKeiko YamamotoAdrian S RayBlaise LippaBryan GoodwinFu-Yang LinHua WangJames E DowlingMin LuQi QiaoT Andrew McTeagueTerence I MoyFrançois PotusSteeve ProvencherOlivier BoucheratSebastien Bonnet

Published in: bioRxiv : the preprint server for biology (2024)

The α5β1 integrin plays a crucial role in pulmonary vascular remodeling.

Keyphrases

pulmonary arterial hypertension
pulmonary hypertension
pulmonary artery
cell adhesion
cell migration
cell therapy
case control
stem cells
human health
clinical trial
coronary artery