Human mesenchymal stem cells-derived conditioned medium inhibits hypoxia-induced death of neonatal porcine islets by inducing autophagy.
Yuzhi XuMengqun TanXiaoqian MaHongde LiXuesong HeZeyi ChenYixiong TanWei NiePengfei RongWei WangPublished in: Xenotransplantation (2019)
Our results demonstrated that huc-MSC-CM improved islet viability and function by increasing autophagy through the PI3K/Akt/mTOR pathway under hypoxic conditions. Additionally, IL-6 plays an important role in the function of huc-MSC-CM.