HLA-DQA1-HLA-DRB1 polymorphism is a major predictor of azathioprine-induced pancreatitis in patients with inflammatory bowel disease.
A WilsonL E JansenR V RoseJ C GregorT PonichN ChandeR KhannaB YanV JairathN KhannaM SeyM BeatonK McIntoshW A TeftRichard B KimPublished in: Alimentary pharmacology & therapeutics (2017)
The class II HLA region (at rs2647087) is an important marker of AZA-induced pancreatitis risk. We propose a simple and clinically implementable algorithm based on rs2647087 and TPMT genotypes for AZA selection and dosing for patients with IBD.