Using Genomic Variation to Distinguish Ovarian High-Grade Serous Carcinoma from Benign Fallopian Tubes.

Jesus Gonzalez BosquetNicholas D CardilloHenry D ReyesBrian J SmithKimberly K LeslieDavid P BenderMichael J GoodheartEric J Devor

Published in: International journal of molecular sciences (2022)

Genomic variation of HGSC can be used to create prediction models which accurately discriminate cancer from benign tissue. Further refining of these models (early-stage samples, other tumor types) has the potential to lead to detection of ovarian cancer in blood with cell free DNA, even in early stage.

Keyphrases

early stage
high grade
low grade
copy number
papillary thyroid
sentinel lymph node
squamous cell
loop mediated isothermal amplification
gene expression
squamous cell carcinoma
radiation therapy
real time pcr
childhood cancer
dna methylation